SIEVEWELL™
Ultra-Precise Single-Cell Analysis Platform
for High Density Research
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Accelerate Discovery
with a Single-Cell Platform
That Seamlessly Fits Your
Workflow
Single cell analysis has revolutionized how scientists study cellular heterogeneity, disease progression, and therapeutic response. Yet, conventional isolation methods often require complex instrumentation or produce inconsistent, low-yield results.
SIEVEWELL Slide offers a high-density, precision-engineered cell array platform that simplifies single-cell isolation using standard lab equipment. Its nanowell design and directional flow system enable efficient, reproducible capture of large numbers of viable single cells - without disrupting your existing workflow.
Built for flexibility, SIEVEWELL supports diverse formats for culture, analysis, and advanced cell-based assays. Whether you're running cytotoxicy studies, rare cell detection, or drug response profiling, SIEVEWELL gives you clarity, consistency, and control.
Superior Single-Cell
Capture Efficiency
Unlike conventional microcavity arrays that rely on statistical Poisson distribution for cell capture, SIEVEWELL utilizes a deterministic approach by directing liquid flow across an array of microcavities. Each cavity is equipped with two precisely fabricated through-holes at the bottom, manufactured using advanced semiconductor technologies.
This innovative mechanism enables:
Higher single-cell capture rates
Consistently exceeds capture rates predicted by the Poisson distribution across various cell types.
On-chip cell culture and imaging
Captured single cells can be cultured directly on the chip and observed using an inverted microscope.
Efficient medium exchange
Through-hole design allows for smooth medium replacement with minimal cell loss or disturbance to the captured cells.
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Ultra-High-Density Cell Arrays
20μm Nanowells
370,000 wells within a compact 17×17 mm area
50μm Nanowells
90,000 wells designed to support both single-cell culture—including spheroid formation—and cell-cell interaction assays
Minimal Cell Loss During Staining
Multi-marker staining workflows - perform sequential staining rounds without compromising sample integrity.
Rare cell detection - increase sensitivity and confidence in identifying low-abundance populations like circulating tumor cells (CTCs).
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Versatile Applications Across Single-Cell Research
From immune cell interaction studies to 3D culture and secretion-based screening, SIEVEWELL supports a wide range of high-impact single-cell applications. Explore key applications for the SIEVEWELL Slide below.
Immune Cell Killing Assays
SIEVEWELL facilitates sophisticated immune cell interaction studies:
NK cell cytotoxicity: Monitor real-time killing of target cells
Immunotherapy research: Assess the efficacy of therapeutic immune cells
Empowering the Next Generation of Single-Cell Discovery
SIEVEWELL empowers researchers across diverse fields—from immunology and oncology to cell therapy and drug discovery—with flexible support to adapt to any workflow. Read below how we are shaping the future of single-cell analysis.
Screening of gene-edited cell libraries
Enables phenotyping of individual gene-edited cells
Stem cell research
Supports detailed characterization of cellular reprogramming
Organoid development
Facilitates the growth of organoids from single cells
Plant cell biology
Enables single-cell analysis for agricultural and synthetic biology research
The SIEVEWELL Difference
SIEVEWELL represents a fundamental advancement in single-cell analysis, combining high capture efficiency, minimal cell loss, and exceptional throughput in a simple, cost-effective format. Its precision-engineered design reduces reagent consumption, shortens imaging time, and eliminates the need for specialized equipment- making high-resolution single-cell analysis more accessible than ever. As the field advances, SIEVEWELL delivers the performance and scalability needed to stay ahead.
See below how we compare over traditional approaches:
SIEVEWELL Slide
Traditional Methods
Superior single-cell capture
Deterministic design exceeds Poisson limitations
Inconsistent
Relies on random cell distribution
Minimal cell loss during staining
Less than 5% loss, even after multiple steps
High cell loss
More than 20% loss with standard protocols
High-throughput capability
Process 90,000-370,000 cells per slide
Low throughput
Only hundreds to thousands of cells
Simple lab setup
No need for custom instrumentation
Specialized equipment required
Often costly and complex
Streamlined protocol
Fewer steps, reduced hands-on time
Cumbersome workflows
Requires multiple transfer and handling steps
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