Custom Monomer & Tetramer Service from MBL Life Sciences
MHC Monomer & Tetramer Production
Cosmo Bio USA, in collaboration with MBL International, provides a comprehensive custom MHC monomer and tetramer service designed to support advanced immunological research. Researchers can request tetramers tailored to specific MHC alleles and peptide sequences, enabling precise detection and monitoring of antigen-specific T cells. This service is ideal for T cell epitope mapping, vaccine development, and cancer immunotherapy research.
Extensive Allele Coverage
This service encompasses a broad selection of over 60 MHC alleles across various species, including human (HLA-A, HLA-B, HLA-C, HLA-E), mouse (H-2), rhesus macaque, and chicken. The wide range of available alleles enables researchers to study immune responses across different genetic backgrounds and experimental models, supporting both basic research and translational applications.
Enhanced Specificity Technology
MBL's tetramers incorporate a patented mutation in the MHC class I heavy chain (alanine to valine at position 245), which minimizes non-specific CD8-MHC interactions, thereby enhancing specificity and reducing background staining. This innovation allows for more accurate detection of rare antigen-specific T cell populations with improved signal-to-noise ratios in flow cytometry applications.
.svg)
.svg)
