MHC Tetramers
High-Performance MHC Tetramers for
Accurate T Cell Detection
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Achieve Precise T Cell identification with
High-Sensitivity MHC Tetramers
For more than 50 years, MBL (Medical & Biological Laboratories Co., Ltd.) has pioneered immunological reagents that empower immunologists and translational researchers. Their MHC Tetramers enable direct, quantitative detection of antigen-specific T cells by flow cytometry—offering the sensitivity and stability required for today's most demanding research in cancer, autoimmunity, infection, and vaccine development.
Through exclusive U.S. distribution by Cosmo Bio USA, researchers gain streamlined access to a diverse catalog of peptide-loaded MHC tetramers and customizable QuickSwitch™ kits for novel antigen discovery.
Download the brochure to explore MBL's rigorously validated peptide-loaded tetramers for accurate, reproducible detection of antigen-specific T cells.
Proven Tetramer Technology for
Comprehensive T Cell Characterization
MBL's tetramers consist of four fluorescently labeled peptide-MHC complexes joined by streptavidin, increasing binding avidity to reveal antigen-specific T cells that monomeric MHC cannot detect. Each reagent undergoes rigorous quality control, HPLC validation, and precision peptide loading to ensure lot-to-lot consistency and low background noise.
Key Features
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antigens, model
systems
(Ala245Val) minimizes nonspecific CD8
binding (Only human and macaque HLA Class I
Tetramers contain the alpha 3 mutation)
Gain Reliable, Reproducible Results for Every Application
The CosmoSonic II supports a wide range of cell disruption and lysis workflows, giving researchers a single, reliable platform for consistent processing across multiple sample types and assays.
High-Parallel Throughput
Process up to 12 × 50 mL or 48 × 0.5 mL tubes at once.
Consistent Temperature Control
Synchronized cooling prevents overheating and protects sample integrity.
Contamination-Controlled Workflow
Hermetically sealed chamber, testable as biohazard-, contamination-, and radioisotope-free.
Safe, Quiet Operation
Sound-absorbing enclosure and anti-tip straps ensure safe daily use.
Easy Setup & Training
Intuitive control panel and automatic water-surface stabilization.
Empowering Innovation Across T Cell Research
MBL Tetramers support T cell research across multiple areas:
Tailored Tetramer & Monomer Solutions to Fit Your Research Needs
MBL's MHC service provides a precision-engineered solution for the development of custom MHC class I and class II tetramers and monomers.
To ensure accuracy and performance, the MBL's team applies a rigorous QC workflow that includes:
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Peptide–MHC binding evaluation through a consensus-driven bioinformatic approach.
Peptide synthesis at >95% purity (typically ~99%) and verified for the expected molecular weight.
In-process and final SEC-HPLC quality control to ensure structural integrity, stability, and reliable performance.
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Have questions or need guidance
selecting the right tetramer?
Our scientific support team is here to help.
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